Sleep Disorders Hub

This video provides an overview of narcolepsy and its symptoms. Also included are patient resources promoting advocacy, education, and valuable tools to personalize treatment plans through shared decision making.

In this video, Dr. Bogan uses an augmented reality animation to describe the extensive impact EDS can have on both medical and psychiatric conditions.

In this video, Dr. Bogan uses an augmented reality animation to examine the regions of the brain that promote sleep and wakefulness, and the neurotransmitters involved.

In this video, Dr. Bogan uses an augmented reality animation to describe the interaction of traditional stimulants such as amphetamines on the sleep-wake cycle. This video will also explain the differences between non-selective stimulants and selective stimulants such as modafinil and armodafinil.

In this video, Dr. Bogan uses an augmented reality animation to explore how through the inhibition of dopamine and norepinephrine reuptake, solriamfetol produces its potent wake-promoting effect and improvement in the symptoms of EDS.

In this video, Dr. Bogan uses an augmented reality animation to explain how pitolisant increases levels of histamine in the brain to decrease symptoms of EDS and improve wakefulness, vigilance, attention, and memory.

• Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline
• Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline
• Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure: An American Academy of Sleep Medicine Clinical Practice Guideline
• Quality Measures for the Care of Patients with Narcolepsy
• Quality Measures for the Care of Adult Patients with Obstructive Sleep Apnea
• Practice Parameters for the Treatment of Narcolepsy and other Hypersomnias of Central Origin
• Practice Parameters for the Indications for Polysomnography and Related Procedures: An Update for 2005
• Practice Parameters for Clinical Use of the Multiple Sleep Latency Test and the Maintenance of Wakefulness Test
• Evaluation, Management and Long-Term Care of OSA in Adults
• Clinical Guideline for the Evaluation, Management and Long-term Care of Obstructive Sleep Apnea in Adults
• One Week Sleep Diary Sample
• Epworth Sleepiness Scale
• Two Week Sleep Diary
• Swiss Narcolepsy Scale
• Idiopathic Hypersomnia Severity Scale (IHSS)
• Sleep Diary Sample
• Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD)
• Narcolepsy Severity Scale (NSS)

• American Academy of Sleep Medicine (AASM) Sleep TM app, a mobile app that directly connects patients to sleep medicine professionals and accredited sleep centers through the AASM SleepTM telemedicine system. The app provides patients convenient access to sleep medicine services on their mobile devices. – Click Here
• Sleep Tuner, FDA-registered sleep sensor, worn on the forehead, to measure blood oxygenation, heart rate, sleep position, and stopped breathing events. It is designed to offer the accuracy of medical sleep studies without the cost or inconvenience. – Click Here
• ResApp, uses a smartphone to detect sleep apnea by sound, delivering a highly-scalable, accurate, and easy-to-use screening test. It uses a machine-learning algorithm to detect the severity of sleep apnea by the sound of a person’s breathing and snoring. A user can put the smartphone next to their bed and it will record their sleeping. – Click Here
• DeepHeart, a deep neural network technology that can detect hypertension and sleep apnea. – Click Here

Infographics

• Healthy Sleep Duration Poster
• Stop the Snore Infographic
• Little Sleep, Big Costs Infographic
• Sleep Apnea Hurts Hearts
• How Too Much Sodium Affects Your Health
• Sodium Myths and Facts for Kids

Websites

• Sleep Education (from the American Academy of Sleep Medicine): http://www.sleepeducation.org
• National Healthy Sleep Awareness Project (from the American Academy of Sleep Medicine):  http://www.sleepeducation.org/healthysleep
• National Sleep Foundation: https://www.sleepfoundation.org
• American Sleep Association: https://www.sleepassociation.org
• National Heart, Lung, and Blood Institute-National Institutes of Health:  https://www.nhlbi.nih.gov/health-pro/resources/sleep

Patient Organizations

• American Sleep Apnea Association: http://www.sleepapnea.org
• Circadian Sleep Disorders Network: http://www.circadiansleepdisorders.org
• Narcolepsy Network: http://narcolepsynetwork.org
• Restless Legs Syndrome Foundation: https://www.rls.org
• Wake Up Narcolepsy: http://www.wakeupnarcolepsy.org/

• Thorpy MJ, Shapiro C, Mayer G, et al. A randomized study of solriamfetol for excessive sleepiness in narcolepsy. Ann Neurol. 2019;85(3):359-370. Download PDF
• Abad VC. An evaluation of sodium oxybate as a treatment option for narcolepsy. Expert Opin Pharmacother. 2019;20(10):1189-1199. Available at https://www.ncbi.nlm.nih.gov/pubmed/31136215.
• Black J, Swick T, Bogan R, et al. Impact of sodium oxybate, modafinil, and combination treatment on excessive daytime sleepiness in patients who have narcolepsy with or without cataplexy. Sleep Med. 2016;24:57-62. Download PDF
• Schweitzer PK, Rosenberg R, Zammit GK, et al. Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial. Am J Respir Crit Care Med. 2019;199(11):1421-1431. Available at https://www.ncbi.nlm.nih.gov/pubmed/30521757.
• Martinez-Garcia MA, Campos-Rodriguez F, Barbé F, et al. Precision medicine in obstructive sleep apnoea. Lancet Respir Med. 2019 May;7(5):456-464. Available at https://www.ncbi.nlm.nih.gov/pubmed/30987857.
• Inoue Y, Miki M, Tabata T. Findings of the Maintenance of Wakefulness Test and its relationship with response to modafinil therapy for residual excessive daytime sleepiness in obstructive sleep apnea patients adequately treated with nasal continuous positive airway pressure. Sleep Med. 2016;27-28:45-48. Available at https://www.ncbi.nlm.nih.gov/pubmed/27938918.
• Scheer D, Schwartz SW, Parr M, et al. Prevalence and Incidence of Narcolepsy in a U.S. Health Care Claims Database, 2008-2010. Sleep. 2019. Epub ahead of print]. Available at https://www.ncbi.nlm.nih.gov/pubmed/31004158.
• Thorpy MJ, Hiller G. The Medical and Economic Burden of Narcolepsy: Implications for Managed Care. Am Health Drug Benefits. 2017;10(5):233-241. – Download PDF
• Hein M, Lanquart JP, Loas G, et al. Prevalence and risk factors of excessive daytime sleepiness in major depression: A study with 703 individuals referred for polysomnography. J Affect Disord. 2019 Jan 15;243:23-32. Available at https://www.ncbi.nlm.nih.gov/pubmed/30223136.
• Kallweit U, Bassetti CL. Pharmacological management of narcolepsy with and without cataplexy. Expert Opin Pharmacother. 2017;18(8):809-817. Available at https://www.ncbi.nlm.nih.gov/pubmed/28443381.
• Mayer G, Piazzi G, Iranzo A, et al. Long-term compliance, safety, and tolerability of sodium oxybate treatment in patients with narcolepsy type 1: a post-authorization, noninterventional surveillance study. Sleep. 2018;41(9). – Download PDF
• Szabo ST, Thorpy MJ, Mayer G, et al. Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy. Sleep Med Rev. 2019;43:23-36. – Download PDF
• Gentina T, Bailly S, Jounieaux F, et al. Marital quality, partner’s engagement and continuous positive airway pressure adherence in obstructive sleep apnea. Sleep Med. 2019;55:56-61. Available at https://www.ncbi.nlm.nih.gov/pubmed/30771736.
• Schöbel C, Knorre S, Glos M, et al. Improved follow-up by peripheral arterial tonometry in CPAP-treated patients with obstructive sleep apnea and persistent excessive daytime sleepiness. Sleep Breath. 2018 Dec;22(4):1153-1160. Available at https://www.ncbi.nlm.nih.gov/pubmed/29956104.
• Avellar AB, Carvalho LB, Prado GF, et al. Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: A systematic review and meta-analysis. Sleep Med Rev. 2016;30:97-107. Available at https://www.ncbi.nlm.nih.gov/pubmed/27865102.
• Gasa M, Tamisier R, Launois SH, et al. Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure. J Sleep Res. 2013;22(4):389-397. – Download PDF
• Inoue Y, Takasaki Y, Yamashiro Y. Efficacy and safety of adjunctive modafinil treatment on residual excessive daytime sleepiness among nasal continuous positive airway pressure-treated Japanese patients with obstructive sleep apnea syndrome: a double-blind placebo-controlled study. J Clin Sleep Med. 2013;9(8):751-757. – Download PDF
• Sukhal S, Khalid M, Tulaimat A. Effect of Wakefulness-Promoting Agents on Sleepiness in Patients with Sleep Apnea Treated with CPAP: A Meta-Analysis. J Clin Sleep Med. 2015;11(10):1179-1186. – Download PDF