Sleep Disorders Hub

Sleep Continuing Education

Stay Informed While Earning Sleep CME Credits

Sleep is an essential component of health and wellness; yet, many people experience disruptions in their sleep-wake cycle that are severe enough to impair physiological and psychosocial functioning. Disorders of the sleep-wake cycle, such as obstructive sleep apnea, narcolepsy and hypersomnia, as well as associated syndromes such as cataplexy and excessive daytime sleepiness, represent significant health problems with short- and long-term consequences. Sleep disorders have been associated with metabolic effects, changes in circadian rhythms, proinflammatory responses, and psychiatric, neurologic, pulmonary, and cardiac conditions, as well as decrements in neurocognitive domains. Likewise, sleep disorders can negatively impact work performance and attendance, and may contribute to increased injuries and accidents, creating a significant economic burden, as well as increased health care utilization and more frequent and longer hospitalizations.

Given the significant impact of sleep disorders, the identification and implementation of safe, effective therapies is paramount. The CME Outfitters Sleep Disorders Hub is designed to provide clinicians with the latest clinical practice guidelines, diagnostic strategies and tools, and scientific updates on current and emerging therapies to optimize the management of sleep disorders. In addition, the Sleep Disorders Hub also provides patient education tools to empower patients to make informed decisions about their care.

Achieving Optimal Outcomes in Patients with Narcolepsy: Aligning Treatment Goals with Patients

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Join Drs. Bogan, Thorpy, and Weaver for an OnDemand symposium as they discuss evidence-based strategies to reduce EDS and cataplexy, among other symptoms, and restore quality of life and functioning in patients with narcolepsy.

Detect and Defeat: Improving Awareness of the Differences in Narcolepsy and Novel Strategies for Treatment

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Join expert faculty in this OnDemand webcast as they discuss effective tools and strategies to improve the accurate and early detection of narcolepsy, as well as the latest evidence on optimal treatment strategies to achieve sustained benefits by improving clinical outcomes and facilitating adherence.

A Clinical Wake Up Call: Diagnostic Strategies and Novel Therapies in Idiopathic Hypersomnia

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This CME Outfitters OnDemand Webcast will feature expert faculty detailing the functional and clinical impact of IH, best practices and the latest tools for an accurate diagnosis, and the efficacy and safety of novel therapies and how they address the unmet needs of people with IH.

Hitting Refresh on Excessive Daytime Sleepiness: Managing Patients with Narcolepsy and Idiopathic Hypersomnia

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This CME Outfitters virtual symposium will take place during the AASM SLEEP 2021 virtual conference. Expert faculty will discuss the spectrum of EDS across the subtypes of narcolepsy, strategies to apply data from recent clinical trials to treatment decision-making, and the impact of emerging agents for the management of EDS in patients with IH.

Lose a Little Sleep, Lose a Lot of Life

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This CMEO Journal Club activity is the first in a three-part series that focuses on the presentation of EDS and evidence-based measures to assess its impact on QoL so that clinicians might better educate patients on the significance of detecting and treating EDS.

Because “Good Enough” is Not Ok: Examining the Need for Novel Therapies in the Management of EDS in OSA and Narcolepsy

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In this second installment of a 3-part journal club series on making sense of the latest clinical data on EDS in obstructive sleep apnea (OSA) and narcolepsy, featuring expert faculty discussing the factors to consider when making treatment selections for patients and how best to personalize treatment strategies, including which patients would be ideal for JZP-258, transitioning patients from one therapy to another, and dosing considerations.

Putting Data into Practice: Applying the Latest Clinical Evidence to Management Strategies

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The final installment of this 3-part journal club series hosted by CME Outfitters highlights the latest clinical evidence on novel therapies for EDS in obstructive sleep apnea (OSA) and narcolepsy and how to incorporate this evidence into optimal treatment planning to reduce the burden of EDS.

The Impact of OSA-Related EDS on HRQoL: Time for a Wake-up Call

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Join Drs. Richard Bogan and Terri Weaver as they discuss case 1 of this 3-part CMEO BriefCase series and provide insight into the extensive impact of OSA-related EDS on psychosocial functioning and HRQoL to promote the need for early intervention.

Crafting an Individualized Plan to Optimize Patient Outcomes: Safe, Effective, and Personalized Treatment

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Join Drs. Richard Bogan and Paula Schweitzer as they discuss case 2 of this 3-part CMEO BriefCase series and provide guidance on the nuances of personalizing treatment selection and strategies to monitor treatment effectiveness to provide safe, effective, long-term care.

Examining the Latest Evidence on EDS and Cataplexy in Narcolepsy: What are the Implications for Your Practice?

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This CME Outfitters podcast will focus on considering individual patient characteristics along with updated clinical parameters and newly approved narcolepsy medications so that clinicians can identify and implement effective treatment to achieve long-term benefits by improving clinical outcomes and therefore patient QOL.

Addressing the Burden of Narcolepsy: Residual Symptoms Are Nothing to Snooze On

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Join Drs. Thorpy and Emsellem in this first installment of a CMEOCast series on EDS in narcolepsy as they inform clinicians not only of the extensive burden imposed by narcolepsy but also diagnostic strategies to facilitate early detection and the implementation of effective treatment.

Differentiators When Choosing Novel Treatment Options for EDS

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This CMEOCast podcast focuses on developing personalized, effective strategies to reduce EDS in patients with OSA or narcolepsy, including an overview of data on incorporating the use of safer, lower sodium alternatives to mitigate EDS without imposing cardiovascular burden.

Breakthroughs in the Management of Idiopathic Hypersomnia: The Future is Now

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This CME Outfitters Snack will help clinicians navigate scientific updates on the safety and efficacy of emerging therapies for IH presented at the Sleep 2021 Annual Meeting and offer insights into best practices for applying those updates to clinical decision-making.

Cardiovascular Comorbidities in Narcolepsy: The Latest Insights on Treatment Options to Mitigate Risks

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This CME Outfitters Snack features expert faculty discussing the latest clinical evidence on the cardiovascular burden of narcolepsy and the need to consider cardiovascular comorbidities and other risk factors to inform treatment planning for patients with narcolepsy.

Real-World Strategies for the Management of Narcolepsy: Highlights from the 2021 Sleep Meeting on Dosing and Titration

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This CME Outfitters Snack will provide clinicians with the latest evidence on real-world strategies for dosing and titrating pharmacotherapies for the management of narcolepsy.

Putting Idiopathic Hypersomnia Treatment Challenges to Rest: The Latest Evidence on the Safety and Efficacy of Emerging Therapies

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This CME Outfitters Snack will examine the latest clinical evidence from the Sleep 2021 Annual Meeting on the safety, efficacy, and dosing of novel treatment strategies for IH, with and without long sleep time.


Narcolepsy: An Animated Overview

This video provides an overview of narcolepsy and its symptoms. Also included are patient resources promoting advocacy, education, and valuable tools to personalize treatment plans through shared decision making.

Impact of EDS: An Animated Tour

In this video, Dr. Bogan uses an augmented reality animation to describe the extensive impact EDS can have on both medical and psychiatric conditions.

Neurotransmitters Involved in the Sleep-Wake Cycle: An Animated Tour

In this video, Dr. Bogan uses an augmented reality animation to examine the regions of the brain that promote sleep and wakefulness, and the neurotransmitters involved.

Interaction of Stimulants with the Sleep-Wake Cycle: An Animated Tour

In this video, Dr. Bogan uses an augmented reality animation to describe the interaction of traditional stimulants such as amphetamines on the sleep-wake cycle. This video will also explain the differences between non-selective stimulants and selective stimulants such as modafinil and armodafinil.

Interaction of Solriamfetol and the Sleep-Wake Cycle: An Animated Tour

In this video, Dr. Bogan uses an augmented reality animation to explore how through the inhibition of dopamine and norepinephrine reuptake, solriamfetol produces its potent wake-promoting effect and improvement in the symptoms of EDS.

Interaction of Pitolisant and the Sleep-Wake Cycle: An Animated Tour

In this video, Dr. Bogan uses an augmented reality animation to explain how pitolisant increases levels of histamine in the brain to decrease symptoms of EDS and improve wakefulness, vigilance, attention, and memory.

Digital Health Tools

  • American Academy of Sleep Medicine (AASM) Sleep TM app, a mobile app that directly connects patients to sleep medicine professionals and accredited sleep centers through the AASM SleepTM telemedicine system. The app provides patients convenient access to sleep medicine services on their mobile devices. – Click Here
  • Sleep Tuner, FDA-registered sleep sensor, worn on the forehead, to measure blood oxygenation, heart rate, sleep position, and stopped breathing events. It is designed to offer the accuracy of medical sleep studies without the cost or inconvenience. – Click Here
  • ResApp, uses a smartphone to detect sleep apnea by sound, delivering a highly-scalable, accurate, and easy-to-use screening test. It uses a machine-learning algorithm to detect the severity of sleep apnea by the sound of a person’s breathing and snoring. A user can put the smartphone next to their bed and it will record their sleeping. – Click Here
  • DeepHeart, a deep neural network technology that can detect hypertension and sleep apnea. – Click Here

Patient Resources



Patient Organizations

Reading Room

  • Thorpy MJ, Shapiro C, Mayer G, et al. A randomized study of solriamfetol for excessive sleepiness in narcolepsy. Ann Neurol. 2019;85(3):359-370. Download PDF
  • Abad VC. An evaluation of sodium oxybate as a treatment option for narcolepsy. Expert Opin Pharmacother. 2019;20(10):1189-1199. Available at
  • Black J, Swick T, Bogan R, et al. Impact of sodium oxybate, modafinil, and combination treatment on excessive daytime sleepiness in patients who have narcolepsy with or without cataplexy. Sleep Med. 2016;24:57-62. Download PDF
  • Schweitzer PK, Rosenberg R, Zammit GK, et al. Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial. Am J Respir Crit Care Med. 2019;199(11):1421-1431. Available at
  • Martinez-Garcia MA, Campos-Rodriguez F, Barbé F, et al. Precision medicine in obstructive sleep apnoea. Lancet Respir Med. 2019 May;7(5):456-464. Available at
  • Inoue Y, Miki M, Tabata T. Findings of the Maintenance of Wakefulness Test and its relationship with response to modafinil therapy for residual excessive daytime sleepiness in obstructive sleep apnea patients adequately treated with nasal continuous positive airway pressure. Sleep Med. 2016;27-28:45-48. Available at
  • Scheer D, Schwartz SW, Parr M, et al. Prevalence and Incidence of Narcolepsy in a U.S. Health Care Claims Database, 2008-2010. Sleep. 2019. Epub ahead of print]. Available at
  • Thorpy MJ, Hiller G. The Medical and Economic Burden of Narcolepsy: Implications for Managed Care. Am Health Drug Benefits. 2017;10(5):233-241. – Download PDF
  • Hein M, Lanquart JP, Loas G, et al. Prevalence and risk factors of excessive daytime sleepiness in major depression: A study with 703 individuals referred for polysomnography. J Affect Disord. 2019 Jan 15;243:23-32. Available at
  • Kallweit U, Bassetti CL. Pharmacological management of narcolepsy with and without cataplexy. Expert Opin Pharmacother. 2017;18(8):809-817. Available at
  • Mayer G, Piazzi G, Iranzo A, et al. Long-term compliance, safety, and tolerability of sodium oxybate treatment in patients with narcolepsy type 1: a post-authorization, noninterventional surveillance study. Sleep. 2018;41(9). – Download PDF
  • Szabo ST, Thorpy MJ, Mayer G, et al. Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy. Sleep Med Rev. 2019;43:23-36. – Download PDF
  • Gentina T, Bailly S, Jounieaux F, et al. Marital quality, partner’s engagement and continuous positive airway pressure adherence in obstructive sleep apnea. Sleep Med. 2019;55:56-61. Available at
  • Schöbel C, Knorre S, Glos M, et al. Improved follow-up by peripheral arterial tonometry in CPAP-treated patients with obstructive sleep apnea and persistent excessive daytime sleepiness. Sleep Breath. 2018 Dec;22(4):1153-1160. Available at
  • Avellar AB, Carvalho LB, Prado GF, et al. Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: A systematic review and meta-analysis. Sleep Med Rev. 2016;30:97-107. Available at
  • Gasa M, Tamisier R, Launois SH, et al. Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure. J Sleep Res. 2013;22(4):389-397. – Download PDF
  • Inoue Y, Takasaki Y, Yamashiro Y. Efficacy and safety of adjunctive modafinil treatment on residual excessive daytime sleepiness among nasal continuous positive airway pressure-treated Japanese patients with obstructive sleep apnea syndrome: a double-blind placebo-controlled study. J Clin Sleep Med. 2013;9(8):751-757. – Download PDF
  • Sukhal S, Khalid M, Tulaimat A. Effect of Wakefulness-Promoting Agents on Sleepiness in Patients with Sleep Apnea Treated with CPAP: A Meta-Analysis. J Clin Sleep Med. 2015;11(10):1179-1186. – Download PDF

Discover additional accredited CME/CE activities and patient resources on the Virtual Education Hub.

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