Tailoring Therapy to Fit the Whole Patient with OSA-Aassociated EDS

This activity is part of a series


Atul Malhotra, MD
Professor of Medicine
University of California San Diego School of Medicine
Research Chief
Pulmonary, Critical Care, Sleep Medicine, and Physiology Division
UC San Diego Health
San Diego, CA
Atul Malhotra, MD

Atul Malhotra, MD, is a pulmonary critical and sleep medicine physician at University of California San Diego (UCSD). He is a research chief and endowed professor of respiratory medicine as well as a former president of the American Thoracic Society. While running a large National Institutes of Health (NIH)-funded laboratory and being active clinically, he has published 455 original manuscripts plus 300 reviews/chapters since 2000.

Statement of Need

The therapeutic armamentarium for obstructive sleep apnea (OSA)-associated excessive daytime sleepiness (EDS) is limited, with few new therapies on the horizon. With just three therapies currently indicated for these patients, health care professionals (HCPs) are tasked with developing personalized and effective dosing and titration strategies for patients with OSA-associated EDS that consider patient behaviors, comorbidities, drug-drug interactions, and more—like in our patient,  Alvin, who is stable and has had some improvement after 8 months on continuous positive airway pressure (CPAP) treatment but still has some difficulty with EDS.

Join us for this third of three BriefCase activities in which our expert faculty interweaves foundational knowledge with exercises for HCPs to practice new learnings with a case that emulates a patient with OSA and EDS seen in clinical practice.

Learning Objective

Develop real-world dosing and titration strategies that personalize treatment for optimal outcomes in patients with EDS associated with OSA.

Financial Support

Supported by an educational grant from Axsome.

Target Audience

Sleep specialists, neurologists, psychiatrists, pulmonologists, primary care practitioners, nurse practitioners (NPs), physician associates (PAs), and pharmacists

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Interprofessional (IPCE) 0.5

This activity was planned by and for the healthcare team, and learners will receive 0.5 Interprofessional Continuing Education (IPCE) Credit for learning and change.

Physicians (ACCME) 0.5

CME Outfitters, LLC, designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses (ANCC) 0.5

This activity is designated for 0.5 contact hours.

Note for California Nurses

This continuing nursing education activity was approved by the California Board of Registered Nursing. CME Outfitters, LLC’s provider number is CEP15510.

Pharmacists (ACPE) 0.5

This application-based activity is approved for 0.5 contact hours (0.05 CEUs) of continuing pharmacy credit.
Activity UAN: JA0007185-0000-23-088-H01-P

PAs (AAPA) 0.5

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid until expiration date listed above. PAs should only claim credit commensurate with the extent of their participation.


Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.5 medical knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

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Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process.

Dr. Malhotra reports the following financial relationships:

Consultant: Lilly; LivaNova; Jazz Pharmaceuticals, Inc.; and ZOLL Medical Corporation

Grants: National Institutes of Health (NIH)

Other financial or material support: ResMed (provided a philanthropic donation to UCSD

Disclosures were obtained from the following peer reviewer and CME Outfitters, LLC, staff, with no disclosures to report::

  • Joshua Caballero, PharmD, BCPP, FCCP (peer reviewer)
  • Susan Perry (planning committee)
  • John Jones, PharmD (planning committee)
  • Susan H. Yarbrough, CHCP (planning committee)
  • Sandra Caballero, PharmD (planning committee)
  • Sharon Tordoff (planning committee)

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

Obtaining Credit

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Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).


Tailoring Therapy to Fit the Whole Patient with OSA-Aassociated EDS
Event Date: 08/16/2023