Cerebrospinal Fluid Levels Change 5 to 10 Years Before the Onset of Alzheimer’s

According to a study in the Archives of General Psychiatry, approximately 90% of patients with MCI and pathologic CSF biomarker levels at baseline develop AD within 9 to 10 years. Levels of Aβ42 are already fully decreased at least 5 to 10 years before conversion to AD dementia, whereas T-tau and P-tau seem to be later markers. [More…]