EGPA Management: Integrating Targeted Therapies to Optimize Outcomes

This activity is part of a series


Michael E. Wechsler, MD, MMSc
Professor of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine
Director, The Cohen Family Asthma Institute
National Jewish Health
Denver, CO
Michael E. Wechsler, MD, MMSc

Michael E. Wechsler is Professor of Medicine in the Division of Pulmonary, Critical Care and Sleep Medicine at National Jewish Health (NJH) in Denver, Director of the NJH/Cohen Family Asthma Institute, and Associate Vice President for Innovation and Industry Relations at NJH. In addition to clinical work in pulmonary and critical care medicine, Professor Wechsler’s research focuses on clinical and translational asthma with emphasis on clinical trials in asthma, novel asthma therapies, bronchial thermoplasty, asthma pharmacogenomics, and management of eosinophilic granulomatosis with polyangiitis (i.e. Churg-Strauss Syndrome). He has led studies focusing on novel biologic agents for asthma and related diseases, including benralizumab, dupilumab, mepolizumab, reslizumab, and tezepelumab. He has published more than 270 peer-reviewed manuscripts relating to asthma, EGPA, and eosinophilic lung diseases. He was a member of the Steering Committee and site Principal Investigator (PI) of the NIH-sponsored Asthma Clinical Research Network (ACRN, now called AsthmaNet), a multicenter asthma clinical trials consortium, and currently serves as the PI of the Denver site of the Precision Intervention in Severe/Exacerbating Asthma (PRECISE) network. A member of the American Society of Clinical Investigation and the Association of American Physicians, he has participated in many different task forces related to the study of eosinophilic lung diseases that were sponsored by the NIH, the FDA, the European Respiratory Society, and the International Eosinophil Society. He is currently Associate Editor of the journal Chest and has served as Associate Editor of the journal Allergy and on the editorial board of the European Journal of Clinical Investigation.

Dr. Wechsler received AB and MMSc degrees from Harvard University in Boston and an MD degree from McGill University in Montreal. He completed medical training at Beth Israel Hospital in Boston, and as part of the Harvard Combined Pulmonary and Critical Care Fellowship Training Program.</br.

Philip Seo, MD, MHS
Director Emeritus, Johns Hopkins Vasculitis Center
Associate Professor of Medicine, Johns Hopkins University
Baltimore, MD
Philip Seo, MD, MHS

Dr. Philip Seo is an Assistant Professor in the Division of Rheumatology. A graduate of Harvard College and the College of Physicians and Surgeons at Columbia University, Dr. Seo completed his Internal Medicine training as a member of the Osler Medical Service at the Johns Hopkins Hospital. Since then, he has worked at Johns Hopkins in several capacities, including as a hospitalist at Johns Hopkins Bayview Medical Center, and as an Assistant Chief of Service of the Department of Medicine at the Johns Hopkins Hospital, before joining the Division of Rheumatology.

His research interests are the assessment and treatment of ANCA-associated vasculitides, including Churg Strauss Syndrome, Wegener’s Granulomatosis, and Microscopic Polyangiitis.

Statement of Need

Eosinophilic granulomatosis with polyangiitis (EGPA) is one of the rarest forms of vasculitis. Increases in interleukin (IL)-5, a principal eosinophil-mobilizing cytokine, result in chronic eosinophilic inflammation and tissue damage to multiple organ systems. Induction and maintenance of remission in EGPA is achieved through the use of various treatment combinations but often involves chronic use of glucocorticoids. Treatments targeting the IL-5 have been developed to decrease glucocorticoid dependence and improve remission rates. In 2017 the first anti-IL-5 antibody was approved for the treatment of non-severe EGPA and has been shown to improve time in remission and reduce the need for chronic glucocorticoid treatment.

During this 30-minute CMEO Snack, Drs. Wechsler and Seo will discuss how to integrate EGPA treatments, including IL-5 targeted therapies, based on current treatment guidelines and patient-specific factors.

Learning Objective

Integrate treatments for EGPA based on current guidelines and patient-specific factors.


Financial Support

This educational activity is supported by an educational grant from GSK.

Target Audience

Physicians, physician associates (PAs), nurse practitioners (NPs), nurses, and pharmacists specializing in rheumatology, allergy/immunology, pulmonology, nephrologist, internal medicine, and primary care medicine.

Credit Information

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Pharmacists/Pharmacy Tech (ACPE) 0.5

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Activity UAN: Pharmacist JA0007185-0000-22-167-H01-P

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MIPS Improvement Activity

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Disclosure Declaration

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Dr. Wechsler reports the following financial relationships:

Advisory Board/Consultant: Amgen Inc.; AstraZeneca; Avalo Therapeutics, Inc.; Boehringer Ingelheim; Cerecor Inc.; Cohero Health, Inc.; CytoReason LTD; Eli Lilly and Company; Equillium Bio; GSK; Incyte; Kinaset Therapeutics; Novartis Pharmaceuticals Corporation; Om Pharma; Phylaxis Bioscience, LLC; PULMATRiX, Inc.; RAPT Therapeutics; Regeneron Pharmaceuticals Inc.; Restorbio; Roche/Genentech, Inc.; Sanofi/Genzyme.; Sentien Biotechnologies, Inc.; Sound Biologics; Tetherex Pharmaceuticals; Teva Pharmaceuticals USA, Inc.; and Upstream Bio

Research Support: Amgen Inc.; AstraZeneca; Avalo Therapeutics, Inc.; GSK; Regeneron Pharmaceuticals Inc.; and Sanofi/Genzyme

Speakers Bureau: AstraZeneca; GSK; Regeneron Pharmaceuticals Inc.; and Sanofi

Dr. Seo reports the following financial relationships:

Financial or Material Support: Janssen Pharmaceuticals, Inc., Data Monitoring Committee (DMC) and Amgen Inc., DMC

Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report:

  • Michael Franks, APRN, AGACNP-BC, FNP-BC (peer reviewer)
  • Thomas Mitchell (planning committee)
  • Kasey Brandt, PharmD (planning committee)
  • Susan H. Yarbrough, CHCP (planning committee)
  • Sandra Caballero, PharmD (planning committee)
  • Sharon Tordoff (planning committee)

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

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EGPA Management: Integrating Targeted Therapies to Optimize Outcomes
Event Date: 05/05/2023