Eosinophilic granulomatosis with polyangiitis (EGPA) is one of the rarest forms of vasculitis. Increases in interleukin (IL)-5, a principal eosinophil-mobilizing cytokine, result in chronic eosinophilic inflammation and tissue damage to multiple organ systems. Induction and maintenance of remission in EGPA is achieved through the use of various treatment combinations but often involves chronic use of glucocorticoids. Treatments targeting the IL-5 have been developed to decrease glucocorticoid dependence and improve remission rates. In 2017 the first anti-IL-5 antibody was approved for the treatment of non-severe EGPA and has been shown to improve time in remission and reduce the need for chronic glucocorticoid treatment.
During this 30-minute CMEO Snack, Drs. Wechsler and Seo will discuss how to integrate EGPA treatments, including IL-5 targeted therapies, based on current treatment guidelines and patient-specific factors.
Integrate treatments for EGPA based on current guidelines and patient-specific factors.
This educational activity is supported by an educational grant from GSK.
Physicians, physician associates (PAs), nurse practitioners (NPs), nurses, and pharmacists specializing in rheumatology, allergy/immunology, pulmonology, nephrologist, internal medicine, and primary care medicine.
It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process.
Dr. Wechsler reports the following financial relationships:
Advisory Board/Consultant: Amgen Inc.; AstraZeneca; Avalo Therapeutics, Inc.; Boehringer Ingelheim; Cerecor Inc.; Cohero Health, Inc.; CytoReason LTD; Eli Lilly and Company; Equillium Bio; GSK; Incyte; Kinaset Therapeutics; Novartis Pharmaceuticals Corporation; Om Pharma; Phylaxis Bioscience, LLC; PULMATRiX, Inc.; RAPT Therapeutics; Regeneron Pharmaceuticals Inc.; Restorbio; Roche/Genentech, Inc.; Sanofi/Genzyme.; Sentien Biotechnologies, Inc.; Sound Biologics; Tetherex Pharmaceuticals; Teva Pharmaceuticals USA, Inc.; and Upstream Bio
Research Support: Amgen Inc.; AstraZeneca; Avalo Therapeutics, Inc.; GSK; Regeneron Pharmaceuticals Inc.; and Sanofi/Genzyme
Speakers Bureau: AstraZeneca; GSK; Regeneron Pharmaceuticals Inc.; and Sanofi
Dr. Seo reports the following financial relationships:
Financial or Material Support: Janssen Pharmaceuticals, Inc., Data Monitoring Committee (DMC) and Amgen Inc., DMC
Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report:
Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.
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