Given the novelty of amyloid-targeting treatments (ATTs) for Alzheimer’s disease, health care professionals specializing in emergency medicine are unfamiliar with best practices for managing patients receiving ATTs who present to emergency settings with symptoms of amyloid-related imaging abnormalities (ARIA). These clinicians need to be aware of the best ARIA management guidance for supportive care, be able to interpret clinical trial protocols for management of serious ARIA events, provide tools and resources to patients, have experience with patient case examples in order to individualize treatment, and communicate with multidisciplinary colleagues about current evidence and best management practices.
The third and final episode of this CMEO BriefCase series focuses on a case involving a patient on an ATT presenting to the emergency department (ED), highlighting ED protocols to streamline care for patients with severe ARIA, recommendations for treatment and supportive care measures, global resources for guidance as the ATT landscape expands, management of ARIA according to best guidance, and communication with ATT-treating clinicians and radiologists.
Manage ARIA in patients receiving ATTs according to best guidance, including communication with ATT treating clinicians and radiologists
This activity is supported by an educational grant from Lilly.
Health care providers, on a global level, who are involved in emergency medicine: Physicians, nurse practitioners (NPs), physician associates (PAs), nurses, triage specialists, and pharmacists
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Dr. Villain reports the following financial relationships:
Grants: Travel grant from GE Healthcare SAS; Merz-Pharma; and UCB Pharma GmbH
Dr. Greenberg reports the following financial relationships:
Speakers Bureau: Genentech, Inc. (ended 12/31/21)
Other financial or material support: Unpaid local principal investigator or sub-investigator for Alector, Inc.; Biogen; Eisai Inc.; Eli Lilly and Company; Janssen Global Services, LLC/Johnson & Johnson; Novo Nordisk A/S; Roche; and UCB Pharma. Unpaid national coordinator for AB Science and ADvantage Therapeutics GmbH.
Unpaid lecturer in symposia organized by Eisai Inc. and the Servier Foundation.
Disclosures were obtained from the following peer reviewer and CME Outfitters, LLC, staff, with no disclosures to report:
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