What to Do: My Patient in the ED May Have ARIA

This activity is part of a series


Nicolas Villain, MD, PhD
Associate Professor of Neurology
Sorbonne University
Institute of Memory and Alzheimer’s Disease
Department of Neurology
Pitié-Salpêtrière Hospital
Assistance Publique – Hôpitaux de Paris
Paris, France
Nicolas Villain, MD, PhD

Nicolas Villain, MD, PhD, is a tenured Associate Professor of Neurology at Sorbonne University, Paris, France and a cognitive and behavioral neurologist at the Institute of Memory and Alzheimer’s Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris. He trained as an MD and a clinical fellow in Paris in Prof. Bruno Dubois’ group and carried out his PhD with Dr. Gaël Chételat in Caen, France, where he worked on multimodal neuroimaging and disconnection mechanisms in Alzheimer’s disease. He currently leads projects on brain network vulnerability using multimodal neuroimaging and on fluid biomarkers of Alzheimer’s disease in Prof. Kaj Blennow’s new group at the Paris Brain Institute.

Jimmy L. Pruitt III, PharmD, BCPS, BCCCP, BCEMP
Emergency Medicine Clinical Pharmacy Specialist
Atrium Health Carolinas Medical Center
Jimmy L. Pruitt III, PharmD, BCPS, BCCCP, BCEMP

Jimmy L. Pruitt III, PharmD, BCPS, BCCCP, BCEMP, is originally from Orlando, Florida, and received his Doctor of Pharmacy from Presbyterian College School of Pharmacy in 2017. He completed a PGY-1 pharmacy residency at Florida Hospital Orlando and then went on to Grady Health System in Atlanta, Georgia, for his PGY2 emergency medicine residency. Dr. Pruitt is currently an emergency medicine clinical pharmacy specialist at the Medical University of South Carolina (MUSC) in Charleston, South Carolina. He was awarded Grady Pharmacist of the Year in 2019 as a PGY2 emergency medicine resident, which was a first in the program’s 30+ year history. In 2020, he obtained Board-Certified Pharmacotherapy Specialist (BCPS) and Board-Certified Critical Care Pharmacist (BCCCP) recognition. Also, in 2020, he won the Society of Academic Emergency Medicine (SAEM) Got Talent competition for his educational series “Pharmacy Friday Pearls,” which was the first time a pharmacist won the event. In 2021, Dr. Pruitt was honored with the Excellence in Diversity award from MUSC College of Pharmacy, was Presbyterian College School of Pharmacy (PCSP) Alumni of the Year, and was keynote speaker for the 2021 PCPS graduation. His professional interests include cardiac arrest, shock syndromes, trauma, and hosting his podcast Pharm So Hard. Dr. Pruitt obtained board certification in emergency medicine in May 2023.

Statement of Need

Symptoms of amyloid-related imaging abnormalities (ARIA) are nonspecific and can be mistaken for multiple diagnoses (e.g., stroke), but there are currently no official clinical guidelines to direct emergency medicine clinicians on assessing symptoms consistent with ARIA in association with amyloid-targeting treatment (ATT). It is imperative that these health care professionals have the skills to develop a best-practice protocol to triage patients who present to the emergency care setting for the likelihood of ARIA in association with ATTs.

The second episode of this CMEO BriefCase series focuses on a patient case that demonstrates real-world challenges such as obtainment of an accurate medical history, imaging needs and interpretations, and what to do if magnetic resonance imaging (MRI) is not accessible.

Learning Objective

At the conclusion of this activity, learners will be able to better:

Develop a best practice protocol to triage patients who present to an emergency care setting for the likelihood of ARIA in association with ATT treatment

Financial Support

This activity is supported by an educational grant from Lilly.

Target Audience

Health care providers, on a global level, who are involved in emergency medicine: physicians, nurse practitioners (NPs), physician associates (PAs), nurses, triage specialists, and pharmacists

Credit Information

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Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process.

Dr. Pruitt reports no financial relationships to disclose.

Dr. Villain reports the following financial relationships:

Grants: Travel grant from GE Healthcare SAS; Merz-Pharma; and UCB Pharma GmbH

Other financial or material support: Unpaid local principal investigator or sub-investigator for Alector, Inc.; Biogen; Eisai Inc.; Eli Lilly and Company; Janssen Global Services, LLC/Johnson & Johnson; Novo Nordisk A/S; Roche; and UCB Pharma. Unpaid national coordinator for AB Science and ADvantage Therapeutics GmbH.  Unpaid lecturer in symposia organized by Eisai Inc. and the Servier Foundation.

Disclosures were obtained from the following CME Outfitters, LLC, staff, with no disclosures to report:

  • Marlon (Tony) Graham, MD (peer reviewer)
  • Elizabeth Naber, MSN, RN, CCRN-K, CNRN, TCRN (peer reviewer)
  • Susan Perry (planning committee)
  • Erin Spencer (planning committee)
  • Susan H. Yarbrough, CHCP (planning committee)
  • Sandra Caballero, PharmD (planning committee)
  • Sharon Tordoff (planning committee)

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

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What to Do: My Patient in the ED May Have ARIA
Event Date: 12/20/2023 at 5:00 am EST