ARIA Alert: Timely Recognition in the Emergency Department

This activity is part of a series


Nicolas Villain, MD, PhD
Associate Professor of Neurology
Sorbonne University
Institute of Memory and Alzheimer’s Disease
Department of Neurology
Pitié-Salpêtrière Hospital
Assistance Publique – Hôpitaux de Paris
Paris, France
Nicolas Villain, MD, PhD

Nicolas Villain, MD, PhD, is a tenured Associate Professor of Neurology at Sorbonne University, Paris, France and a cognitive and behavioral neurologist at the Institute of Memory and Alzheimer’s Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris. He trained as an MD and a clinical fellow in Paris in Prof. Bruno Dubois’ group and carried out his PhD with Dr. Gaël Chételat in Caen, France, where he worked on multimodal neuroimaging and disconnection mechanisms in Alzheimer’s disease. He currently leads projects on brain network vulnerability using multimodal neuroimaging and on fluid biomarkers of Alzheimer’s disease in Prof. Kaj Blennow’s new group at the Paris Brain Institute.

Ana M. Franceschi, MD, PhD
Associate Professor of Radiology 
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell 
The Feinstein Institutes for Medical Research 
Neuro-PET Imaging 
Lenox Hill Hospital
New York, NY

Statement of Need

Patients with Alzheimer’s disease receiving amyloid-targeting treatments (ATTs) are at risk for improper evaluation of amyloid-related imaging abnormalities (ARIA) in emergency care settings. Emergency medicine clinicians currently have insufficient clinical guidance pertaining to ARIA and its presentation in these patients. Imaging characteristics of ARIA can overlap with other imaging abnormalities, and it is important to recognize this for further investigation and implications for management. It is imperative that health care professionals in this setting routinely evaluate patients for suspected ARIA and be aware of ARIA signs and symptoms, assessing patient-related risk factors and timing of occurrence.

The first episode of this CMEO BriefCase series focuses on a patient case that requires differentiating ARIA from other conditions with a similar presentation in the emergency care setting, highlighting ARIA-related symptoms, listing other clinical manifestations of ARIA as described in clinical trials, and reviewing contraindicated medications for patients receiving an ATT.

Learning Objective

Differentiate ARIA from other conditions with a similar presentation in emergency care settings

Financial Support

This activity is supported by an educational grant from Lilly.

Target Audience

Health care providers, on a global level, who are involved in emergency medicine: physicians, nurse practitioners (NPs), physician associates (PAs), nurses, triage specialists, and pharmacists

Credit Information

Jointly accredited provider

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Interprofessional (IPCE) 0.5

This activity was planned by and for the healthcare team, and learners will receive 0.50 Interprofessional Continuing Education Credit for learning and change.

Physicians (ACCME) 0.5

CME Outfitters, LLC, designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses (ANCC) 0.5

This activity is designated for 0.50 contact hours.

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Pharmacists (ACPE) 0.5

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PAs (AAPA) 0.5

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Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.50 medical knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

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Royal College MOC

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Through a mutual recognition agreement between the AMA and the UEMS-EACCME, European physicians completing an e-learning activity from a US-based ACCME-accredited CME provider can use AMA PRA Category 1 Credit™ toward their credit requirements. CME Outfitters is based in Radnor, Pennsylvania, USA. Please retain your certificate as proof of completion.

Disclosure Declaration

Dr. Villain reports the following financial relationships:

Grants: Travel grant from GE Healthcare SAS; Merz-Pharma; and UCB Pharma GmbH
Other financial or material support: Unpaid local principal investigator or sub-investigator for Alector, Inc.; Biogen; Eisai Inc.; Eli Lilly and Company; Janssen Global Services, LLC/Johnson & Johnson; Novo Nordisk A/S; Roche; and UCB Pharma. Unpaid national coordinator for AB Science and ADvantage Therapeutics GmbH. Unpaid lecturer in symposia organized by Eisai Inc. and the Servier Foundation.

Dr. Franceschi reports the following financial relationships:

Advisory Board: Biogen and Genentech, Inc./Roche
Consultant: Biogen; Blue Earth Diagnostics;; Eisai Inc.; Genentech, Inc./Roche; Icometrix; Life Molecular Imaging; and Puer
Research Support: Life Molecular Imaging


The following individuals have no financial relationships to disclose:

Marlon (Tony) Graham, MD (Peer Reviewer)
Elizabeth Naber, MSN, RN, CCRN-K, CNRN, TCRN (Peer Reviewer)
Susan Perry (Planning Committee)
Erin Spencer (Planning Committee)
Susan H. Yarbrough, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

Obtaining Credit

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Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).


ARIA Alert: Timely Recognition in the Emergency Department
Event Date: 01/10/2024 at 5:00 am EST