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The inflammatory cytokine interleukin (IL)-23 has been implicated in the pathology of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract. The stimulation of pathogenic Th-17 cell formation by IL-23 and the subsequent ongoing bowel inflammation via …

Patients with Crohn’s disease (CD) frequently experience bowel urgency, a symptom resulting in rushing to the bathroom and sometimes causing loss of bowel control. The symptom of bowel urgency dramatically impacts patient quality of life (QoL), and can lead to …