A NICU Clinician’s Guide to Rapid Whole Genome Sequencing Test Results: Communication and Clinical Decision-Making


Rebecca J. Burke, MD, PhD
Assistant Professor of Pediatrics
Division of Neonatology and Medical Genetics
Penn State Health Milton S. Hershey School of Medicine
Hershey, PA
Rebecca J. Burke, MD, PhD

Rebecca Burke, MD, PhD, is an assistant professor of pediatrics within the divisions of neonatal-perinatal medicine and medical genetics at Penn State Health Milton S. Hershey School of Medicine. She received her medical and graduate degrees from the University of Arkansas for Medical Sciences in Little Rock, AK. She completed her medical residency in general pediatrics at Thomas Jefferson University/ Nemours Children’s Hospital née AI duPont Hospital for Children in Wilmington, DE, where she realized her calling in medicine was to care for fragile neonates and children with rare genetic disorders. She then completed a combined neonatology and clinical genetics fellowship at Texas Children’s Hospital-Baylor College of Medicine in Houston, TX.

Dr. Burke is a passionate advocate for children with complex medical conditions and their families. In addition to her neonatology and genetics practices, she participates in undergraduate and graduate medical education with a goal to increase genetic literacy and awareness among all medical specialties. Her clinical interests include exome and genome sequencing in newborns, and prenatal consultation for families with pregnancies complicated by fetal anomalies.















Wendy K. Chung, MD, PhD
Chief, Department of Pediatrics
Boston Children’s Hospital
Mary Ellen Avery Professor
Harvard Medical School
Boston, MA
Wendy K. Chung, MD, PhD

Wendy Chung, MD, PhD, a clinical and molecular geneticist, is the Chief of the Department of Pediatrics at Boston Children’s Hospital and the Mary Ellen Avery Professor at Harvard Medical School.  She received her bachelor’s degree in biochemistry from Cornell University, her medical degree from Cornell University Medical College, and her doctorate in genetics from The Rockefeller University.

Dr. Chung directs National Institutes of Health (NIH)-funded research programs in human genetics of pulmonary hypertension, breast cancer, obesity, diabetes, autism, birth defects—including congenital diaphragmatic hernia—and congenital heart disease. She is a leader in the ethical, legal, and social implications of genomics, and leads the National Organization of Rare Disorders Center of Excellence at Columbia University. She is a recipient of the New York Academy of Medicine Medal for Distinguished Contributions in Biomedical Science and the Rare Impact Award from the National Organization of Rare Disorders, and is a member of the National Academy of Medicine and the American Academy of Physicians.


Michelle Fergus
Patient Caregiver
Michelle Fergus

Michelle Fergus is a professional, a sister, a fiancé, and a mom to 3-year-old Michael, who has a rare genetic disorder called hereditary fructose intolerance (HFI). Michelle and her partner, Mick, found themselves in a true S.O.S. situation when their son was hospitalized at 3-months old. His first week in the hospital provided no answers, and the second week produced only guesses, until a doctor suggested genetic testing. If their son had not undergone testing, he would not be with them today—genetic testing saved his life. Since then, they have been educating themselves on everything associated with HFI.

Statement of Need

Join our expert faculty as they discuss the expanding and vital role of genetic testing in identifying underdiagnosed conditions in the NICU, the impact of inequitable testing and referral delays on clinical management, and the importance of non-geneticist clinicians accurately reading and interpreting genetic tests. Expert faculty will demonstrate how to read, interpret, and discuss genetic test results with patients and caregivers, and the caregiver journey will be woven throughout the discussion to highlight strategies to bridge the disconnect between caregivers and clinicians.

This 60-minute program will explore real-world applications of the data to practice, with a diverse panel offering unique perspectives on the genetic testing landscape in NICU settings.

Learning Objectives

  • Implement a comprehensive, equitable approach to genetic testing in NICU settings to identify under-recognized genetic conditions.
  • Interpret genetic testing results in NICU settings to improve early referral and clinical management for patients and caregivers.
  • Develop an effective communication plan for the discussion of genetic results in the absence of genetic specialist support with caregivers in NICU settings.

Financial Support

This program has been supported by an independent educational grant from GeneDx, LLC.

Target Audience

Physicians, physician associates (PAs), nurse practitioners (NPs), pharmacists, and nurses practicing in a NICU clinical setting.

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Interprofessional (IPCE) 1.0

This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education (IPCE) Credit for learning and change.

Physicians (ACCME) 1.0

CME Outfitters, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses (ANCC) 1.0

This activity is designated for 1.0 contact hour.

Note for California Nurses

This continuing nursing education activity was approved by the California Board of Registered Nursing. CME Outfitters, LLC’s provider number is CEP15510.

Pharmacists (ACPE) 1.0

This application-based activity is approved for 1.0 contact hour (0.10 CEUs) of continuing pharmacy credit.
Activity UAN: JA0007185-0000-23-054-H01-P

PAs (AAPA) 1.0

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until the expiration date listed above. PAs should only claim credit commensurate with the extent of their participation.

Pediatricians (ABP MOC) 1.0

Successful completion of this CME activity, which includes participation in the activity and individual assessment of and feedback to the learner, enables the learner to earn up to 1.0 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process.

Dr. Burke reports no financial relationships to disclose.

Dr. Chung reports the following financial relationships: Advisory Board: Regeneron Genetics Center, Grants: Sanofi, Other financial or material support: Board of Directors Prime Medicine.

Ms. Fergus reports no financial relationships to disclose.

Disclosures were obtained from the CME Outfitters, LLC staff; no disclosures to report:

  • Michael Franks, APRN, AGACNP-BC, FNP-BC
  • Nichole Lainhart (planning committee)
  • Kellie Busby, PharmD (planning committee)
  • Susan H. Yarbrough, CHCP (planning committee)
  • Sandra Caballero, PharmD (planning committee)
  • Sharon Tordoff (planning committee)

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (75% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit our Privacy & Confidentiality page.

Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).


A NICU Clinician’s Guide to Rapid Whole Genome Sequencing Test Results: Communication and Clinical Decision-Making
Event Date: 05/24/2023 at 4:00 am EST