Dr. Siegel is a practicing physician-scientist specializing in the treatment of schizophrenia and psychosis. He comes to USC after 20 years at the University of Pennsylvania, where he had active roles in research, teaching and clinical care. Dr. Siegel received his M.D. and Ph.D. in Neurobiology at the Mount Sinai School of Medicine in 1996 after completing an undergraduate degree in Neuroscience at Colgate University in 1986. He later completed residency in Psychiatry and a Fellowship in Neuropsychiatry at the University of Pennsylvania before joining the faculty in 2001.

Dr. Siegel has made contributions to understanding the basic neurobiology of schizophrenia, autism, drug abuse and nicotine dependence, as well as making significant contributions in the translation of his research to the bedside. His laboratory uses animal models to evaluate EEG and event related brain activity, combined with behavioral and molecular studies. Additionally, his laboratory has established new methods for the treatment of schizophrenia by inventing long acting biodegradable implants, now under development for clinical application. His work has been supported by federal, state, foundation, and industry sources over the past 20 years. He has published more than 130 manuscripts spanning topics related to drug abuse, basic research in animal models of schizophrenia and autism, as well as clinical aspects of schizophrenia. He is on the editorial board of several leading journals related to psychiatry and neurobiology.