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How Low Can You Go? Targeting of Deep Remission in the Management of Crohn’s Disease

Crohn’s disease (CD) can cause progressive bowel damage, impaired quality of life, and permanent disability. Severity and presentation can vary widely from person to person, necessitating an individualized treatment approach. The use of more readily available imaging modalities such as …

Optimizing Ulcerative Colitis Management: Navigating Challenges and Enhancing Outcomes in Managed Care

Ulcerative colitis (UC) affects around three million people in the United States. Delays in treatment coverage approval, costs of managing the disease, and uncertainties around new treatment options significantly impact how well patients react to treatment, and short- and long-term …

Cytomegalovirus in Stem Cell and Kidney Transplant: Overcoming the Limitations of Conventional Antiviral Therapy

Cytomegalovirus (CMV) remains a major concern in both solid organ transplantation (SOT) and hematopoietic stem cell transplant (HSCT), primarily due to challenges related to treatment selection and monitoring, management of drug-related adverse events, and resistant/refractory disease. To minimize the impact …

Racial and Ethnic Disparities in the Context of New and Emerging Treatments for Hemophilia

New and emerging therapies for hemophilia are transforming clinical pathways in patient care. Such therapies include extended half-life products, non-factor/rebalancing therapies, and even gene therapies. But while this expanding armamentarium is a triumph in the evolution of hemophilia prophylaxis and …

Does Labeling the Level of Severity in Hemophilia Block Access to Optimized Care?

People with mild or moderate hemophilia may struggle to get prophylactic treatment because their disease severity classification does not always match their bleeding symptoms. Additionally, racial and ethnic minority groups with hemophilia often face systemic and socioeconomic circumstances that prevent …

Stewards of Stem Cell and Kidney Transplantation: The Critical Role of Pharmacists in Staving Off CMV Infection

Cytomegalovirus (CMV) is a condition with high seroprevalence in the U.S. population and remains a primary concern in solid organ transplants, particularly allogeneic hematopoietic stem cell transplants (HSCTs) and kidney transplants. Pharmacists are an integral part of the team-based care …

Unraveling the Neuroinflammatory Pathology and Disease-Modifying Targets of Alzheimer’s Disease

Though the longstanding treatment focus for patients with Alzheimer’s disease (AD) has been on amyloid-beta and tau protein accumulation in the brain, evidence continues to spotlight neuroinflammation as a key contributor to AD progression. The presence of toxic amyloid-beta species …