Integrating Clinical Trial Evidence into Global HIV Practice

Statement of Need

Despite significant advances in human immunodeficiency virus (HIV) care, there are persistent gaps in translating clinical trial evidence into real-world practice, limiting optimal outcomes. Clinicians must keep pace with a rapidly evolving treatment landscape—including antiretroviral therapy (ART) such as long-acting injectables (LAIs)—while navigating guideline updates, resource constraints, and regional disparities. Challenges such as suboptimal implementation of rapid ART initiation, limited provider familiarity with emerging data, and real-world issues such as adherence and discontinuation highlight the need for improved clinical competency. Targeted, globally relevant education is needed to help clinicians interpret current evidence, integrate new therapies into diverse settings, individualize treatment, and implement practical strategies that improve access and patient outcomes.

In this CMEO Snack, expert faculty will discuss recent clinical trial and real-world data on the efficacy and safety of novel and emerging HIV therapies, including LAIs, and how treatment guidelines have evolved across global frameworks. Faculty will also examine how emerging evidence may shape the landscape of future clinical practice in different regions.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

Evaluate the latest efficacy and safety data from recent clinical trials for novel and emerging therapies for HIV, including long-acting injectables

Financial Support

This activity has been supported by an independent educational grant from Gilead Sciences, Inc.

Target Audience

HIV/infectious disease (ID) specialists, primary care practitioners (PCPs), general practitioners (GPs), physician associates (PAs), nurse practitioners (NPs), nurses, and pharmacists in key regions globally: United States, Europe, Africa, and Asia

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME) 1.0

CME Outfitters, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Pharmacists (ACPE) 1.0

This application-based activity is approved for 1.00 contact hours (0.1 CEUs) of continuing pharmacy credit (JA0007185-0000-26-085-H01-P).

Nurses (ANCC) 1.0

This activity is designated for 1.0 contact hours.

California Residents: Provider approved by the California Board of Registered Nursing, Provider # CEP 15510, for 1.0 Contact Hours.

Physician Associates (AAPA): 1.0

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until 10/23/2027. PAs should only claim credit commensurate with the extent of their participation.

ABIM MOC 1.0

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

UEMS-EACCME®

Through a mutual recognition agreement between the AMA and the UEMS-EACCME, European physicians completing an e-learning activity from a US-based ACCME-accredited CME provider can use AMA PRA Category 1 Credit™ toward their credit requirements. CME Outfitters is based in Radnor, Pennsylvania, USA. Please retain your certificate as proof of completion.

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Faculty

Dr. Wohl reports the following financial relationships:

Advisory Board: Gilead Science; Merck & Co., Inc.; Theratechnologies Inc.; and ViiV Healthcare

Research Support: Gilead Sciences; Merck & Co., Inc.; and ViiV Healthcare

Dr. Avihingsanon reports the following financial relationships:

Research Support: B-Sure; BioNet-Asia Co., Ltd; Gilead Sciences; GlaxoSmithKline Biologicals SA (GSK); and MSD (Thailand) Ltd

Dr. Ogbuagu reports the following financial relationships:

Advisory Board: Gilead Sciences and ViiV Healthcare

Consultant: Gilead Sciences

Prof. Orkin reports the following financial relationships:

Advisory Board: Gilead Sciences, Inc.; GSK; MSD (Merck Sharp & Dohme); and ViiV Healthcare

Grants: Gilead Sciences, Inc.; GSK; MSD (Merck Sharp & Dohme); and ViiV Healthcare

Speakers Bureau: Bavarian Nordic; Gilead Sciences, Inc.; GSK; MSD (Merck Sharp & Dohme); and ViiV Healthcare

Patient Planners

Mr. Raif Derrazi reports the following financial relationships:

Advisory Board: ViiV Healthcare

Other financial or material support: Occasional Partnerships: ViiV Healthcare

Ms. Angelina Namiba reports no financial relationships to disclose.

Mr. Prasanth Veerapandiyan reports no financial relationships to disclose.

The following individuals have no financial relationships to disclose:

Rebecca Vargas-Jackson, MD (Peer Reviewer)
Albert Eubanks, Jr., RN (Peer Reviewer)
Susan Perry (Planning Committee)
Estelle Perera (Planning Committee)
Andrea Perseghin, EdD (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (0% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).

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Integrating Clinical Trial Evidence into Global HIV Practice

Faculty

Statement of Need

Learning Objectives

Financial Support

Target Audience