Individualizing HIV Treatment for Diverse Populations

Although advances in antiretroviral therapy (ART) have transformed human immunodeficiency virus (HIV) into a manageable chronic condition, important gaps persist in the consistent, equitable application of care across diverse populations and global settings. Rapid innovation—including long-acting injectable (LAI) and multi-mechanism therapeutic approaches—has outpaced guideline implementation and clinician familiarity, contributing to suboptimal treatment selection and delayed adoption. Health care professionals face ongoing challenges integrating emerging evidence into practice, particularly in resource-limited settings, while also addressing complex patient factors such as adherence, resistance risk, comorbidities, and social drivers of health. As a result, there is a critical need for targeted, globally relevant education to strengthen clinician competence in applying evolving guidelines, individualizing treatment decisions, and incorporating patient preferences and cultural considerations to improve outcomes and reduce disparities in HIV care.

In this CMEO Snack, expert faculty will discuss global HIV treatment guidelines and available ART regimens, including standard and long-acting options, with a focus on selecting optimal, evidence-based ART tailored to individual patient needs and preferences. Faculty will also explore simplification and switching of treatments, pre-switch evaluation, identification of heavily treatment-experienced patients and those requiring special considerations, counseling on dose frequency, and the importance of culturally responsive, patient-centered communication across diverse global settings.

At the conclusion of this activity, learners will be able to better:

• Select appropriate HIV treatment regimens for diverse patient populations based on the latest trial data, guideline recommendations, and patient preferences

This activity has been supported by an independent educational grant from Gilead Sciences, Inc.

HIV/infectious disease (ID) specialists, primary care practitioners (PCPs), general practitioners (GPs), physician associates (PAs), nurse practitioners (NPs), nurses, and pharmacists in key regions globally: United States, Europe, Africa, and Asia

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Faculty

Dr. Madison reports the following financial relationships:

Advisory Board: ViiV Healthcare

Consultant: GSK

Employment: UCSF National Clinician Consultation Center (NCCC) part-time

Stock Shareholder (ownership interest): Pills2Me; Wellness and Equity Alliance

Dr. Barber reports the following financial relationships:

Advisory Board: Gilead Sciences, Inc.; MSD; and ViiV Healthcare

Consultant: Gilead Sciences, Inc., MSD; and ViiV Healthcare

Speakers Bureau: Gilead Sciences, Inc.; Johnson & Johnson; MSD; and ViiV Healthcare

Dr. Bekker reports the following financial relationships:

Other financial or material support: Gilead Sciences, Inc.; MSD (PTY) LTD; and ViiV Healthcare

Dr. Solomon reports the following financial relationships:

Advisory Board: Merck & Co., Inc.

Grants: Abbott Laboratories

Research Support: Abbott Laboratories

Other financial or material support: Honorarium from Gilead Sciences, Inc. to serve on a review committee

Patient Planners

Mr. Raif Derrazi reports the following financial relationships:

Advisory Board: ViiV Healthcare

Other financial or material support: Occasional Partnerships: ViiV Healthcare

Ms. Angelina Namiba reports no financial relationships to disclose.

Mr. Prasanth Veerapandiyan reports no financial relationships to disclose.

The following individuals have no financial relationships to disclose:

Rebecca Vargas-Jackson, MD (Peer Reviewer)
Albert Eubanks, Jr., RN (Peer Reviewer)
Susan Perry (Planning Committee)
Estelle Perera (Planning Committee)
Andrea Perseghin, EdD (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

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