Balancing Pain Relief and Safety: The Opioid REMS Advantage

This activity is part of a series

Statement of Need

Chronic, subacute, and acute pain remain among the most common and complex challenges encountered in clinical practice. Inadequate pain management contributes to diminished quality of life, impaired function, and increased healthcare utilization. At the same time, the ongoing opioid crisis underscores the need for safe, evidence-based approaches to prescribing and monitoring opioid therapy. Clinicians must be equipped to recognize the multifactorial biopsychosocial influences on pain, apply validated assessment tools, and incorporate national guidelines to balance effective pain relief with patient safety. Enhanced provider competency in multimodal pain management, patient counseling, and identification of opioid misuse risk—including application of DSM-5 criteria for opioid use disorder (OUD)—is essential to optimizing outcomes while minimizing harm.

This CMEO Podcast will feature a simulated discussion with practical, real-world insight into chronic pain management. Listeners will learn to identify the physiologic biopsychosocial factors that shape pain experiences, utilize pain assessment tools to reinforce patient-centered and evidence-based management approaches, apply recommendations from the 2022 CDC Guideline for Prescribing Opioids to create safe and effective treatment plans, and develop additional valuable skills and strategies that improve outcomes for patients living with chronic pain.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

  • Identify physiologic biopsychosocial factors that influence different etiologies of pain
  • Utilize pain assessment tools that reinforce approaches to the appropriate management of pain
  • Implement strategies from the 2022 CDC Guideline for Prescribing Opioids into the development of safe and effective pain management plans for patients with acute, subacute, and chronic pain
  • Counsel patients on multimodal pain management to optimize safe and effective, multimodal treatment plans as well as safe storage and disposal
  • Evaluate opioid nonmedical use risk when developing multimodal pain management plans

Financial Support

​​This activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies.

Please click here for a listing of REMS Program Companies. This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the U.S. Food and Drug Administration (FDA).

Target Audience

Physicians, physician associates (PAs), nurse practitioners (NPs), nurses, dentists, and pharmacists

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Physicians (ACCME) 1.0

CME Outfitters, LLC, designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Pharmacists (ACPE) 1.0

This application-based activity is approved for 1.00 contact hours (0.1 CEUs) of continuing pharmacy credit (JA0007185-0000-25-110-H08-P).

Nurses (ANCC) 1.0

This activity is designated for 1.00 contact hours.

California Residents: Provider approved by the California Board of Registered Nursing, Provider # CEP 15510, for 1.00 Contact Hours.

Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology. 

Interprofessional (IPCE) 1.0

This activity was planned by and for the healthcare team, and learners will receive 1.00 Interprofessional Continuing Education Credit for learning and change.

Physician Associates (AAPA) 1.00

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. Approval is valid until 12/18/2026. PAs should only claim credit commensurate with the extent of their participation.

ADA CERP 1.0

CME Outfitters, LLC is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry. Concerns or complaints about a CE provider may be directed to the provider or to the Commission for Continuing Education Provider Recognition at ADA.org/CERP.

CME Outfitters, LLC designates this activity for 1.00 continuing education credits.

Concerns or complaints about a CE provider may be directed to the provider, or to the Commission for Continuing Education Provider Recognition at ADA.org/CERP.

ABIM MOC 1.0

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

The following individuals have no financial relationships to disclose:

Jeffrey Helfand, DO (Peer Reviewer)
Michael Franks, APRN, AGACNP-BC, FNP-BC (Peer Reviewer)
Evan Luberger (Planning Committee)
Leah Zadrozny, DVM, PhD (Planning Committee)
Scott J. Hershman, MD, FACEHP, CHCP (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Obtaining Credit

Post-tests, credit request forms, and activity evaluations must be completed online (requires free account activation), and participants can print their certificate or statement of credit immediately (70% pass rate required). This website supports all browsers except Internet Explorer for Mac.

Questions about this activity?

Call us at 877.CME.PROS (877.263.7767).

PD-118-121825-62

Balancing Pain Relief and Safety: The Opioid REMS Advantage
Event Date: 12/18/2025