Rethinking Suppression: GnRH Antagonists and Contemporary Endometriosis Management

Endometriosis is a chronic inflammatory condition that remains underrecognized and undertreated, leaving many individuals of reproductive age with daily pain and disruption. Patients often face preference‑sensitive decisions about pain management, contraception, and fertility without clear guidance, frequently after years‑long diagnostic delays. Although gonadotropin‑releasing hormone (GnRH) antagonists and other contemporary therapies have expanded options for endometriosis‑associated pain, many clinicians remain anchored to NSAIDs and combined hormonal contraceptives, leading to suboptimal selection and sequencing of non‑surgical treatments. Community clinicians, particularly in underserved settings, face additional challenges due to limited resources and specialty support. By equipping clinicians with cutting-edge education, we can modernize and optimize treatment for a patient population that has waited far too long for compassionate care.

In this CME Outfitters Snack, expert faculty will demonstrate evidence‑based use of GnRH antagonists within non‑surgical management, including patient selection, dosing, monitoring, and positioning. Faculty will model how to individualize therapy by integrating patient goals, clinical characteristics, and current evidence into tailored medical plans that strengthen therapeutic sequencing and shared decision‑making.

At the conclusion of this activity, learners will be able to better:

• Apply evidence-based use of GnRH antagonists for endometriosis-associated pain within non-surgical management, including appropriate patient selection, dosing strategies, monitoring, and treatment positioning
• Individualize non-surgical endometriosis treatment by integrating patient goals, key clinical characteristics, and current evidence into a tailored medical plan

Supported by an educational grant from Sumitomo Pharma America.

Primary: OB/GYNs and primary care providers (PCPs) who evaluate and care for patients with suspected or diagnosed endometriosis and endometriosis-associated pain
Secondary: Women’s health-focused nurse practitioners (NPs), physician associates (PAs), registered nurses, and pharmacists

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Shannahan reports no financial relationships to disclose.

Dr. Taylor reports the following financial relationships:

Advisory Board: Merti

Consultant: Dot

Research Support: AbbVie Inc

The following individuals have no financial relationships to disclose:

Rebecca Vargas-Jackson, MD (Peer Reviewer)
Shirley Michelle Franks, DNP, APRN, FNP-BC, PMC MSN Ed (Peer Reviewer)
Keshia Pitt, PhD (Planning Committee)
Alexis Oneca (Planning Committee)
Leah Zadrozny, DVM, PhD (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

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