Complicated UTI in Real Time: An Interactive Care Pathway Simulation

Complicated urinary tract infections (cUTIs) represent one of the most challenging and rapidly evolving areas of infectious disease management. Often more severe and harder to treat than standard UTIs, cUTIs are associated with underlying structural or functional abnormalities of the urinary tract that can lead to significant patient morbidity and poor clinical outcomes. Clinicians face increasingly diverse cUTI presentations, rising antimicrobial resistance, and a constantly shifting treatment landscape while frequently lacking the knowledge to make timely, evidence-based decisions. To keep pace with updated clinical guidelines and innovative antimicrobial therapies, clinicians and multidisciplinary care teams need practical, up-to-date education that bridges the gap between the latest evidence and real-world patient care for individuals living with cUTI.

In this CME Outfitters AI-powered precision learning activity, expert faculty will apply burden and acuity indicators to classify UTI presentations as localized vs systemic and anticipate downstream site-of-care and resource implications. Learners will be shown how to construct evidence-based empiric and targeted treatment regimens for multi-drug-resistant pathogens by integrating updated clinical algorithms and novel antimicrobial data. Faculty will model implementation of stewardship-driven transition protocols for cUTI, including site-of-care decisions and discharge planning to reduce avoidable readmission.

At the conclusion of this activity, learners will be able to better:

• Apply burden and acuity indicators to classify UTI presentations as localized vs systemic and anticipate downstream site-of-care and resource implications
• Construct evidence-based empiric and targeted treatment regimens for multi-drug-resistant pathogens by integrating updated clinical algorithms and novel antimicrobial data
• Implement stewardship-driven transition protocols for cUTI, including site-of-care decisions and discharge planning to reduce avoidable readmission

This educational activity is supported by an independent medical education grant from GSK.

Urologists, infectious disease physicians, hospitalists, emergency medicine clinicians, physician associates (PAs), nurse practitioners (NPs), and pharmacists

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Gupta reports the following financial relationships:

Advisory Board & Consultant: GSK; Innovative Diagnostics; Iterum Therapeutics; Pfizer Inc.; and UTILITY Therapeutics

Grants & Research Support: NIH grant Co-Investigator (hernia mesh infections); and VA HSRD grant Co-Investigator (preoperative urine cultures)

Stock Shareholder (directly purchased): Lilly and Replimune Group Inc.

The following individuals have no financial relationships to disclose:

Alaa Bawaneh, MD, PhD (Peer Reviewer)
Michael Franks, APRN, AGACNP-BC, FNP-BC (Peer Reviewer)
Keshia Pitt, PhD (Planning Committee)
Leah Zadrozny, DVM, PhD (Planning Committee)
Andrea Perseghin, EdD (Planning Committee)
Sandra Caballero, PharmD (Planning Committee)
Sharon Tordoff (Planning Committee)

*All identified conflicts of interest have been mitigated.

Unlabeled Use Disclosure
Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, planners, and reviewers do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

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