FB-002 Post Test Step 1 of 2 50% Name* First Last Email* Retinitis pigmentosa usually affects which cell type first?* A. Cones B. Rods C. RPE D. None of the above Stargardt disease:* A. Only affects adults B. Is caused by mutations in RPE65 C. Is caused by buildup of toxins in RPE cells D. Can be caused by one of seven genes Antisense oligonucleotides are used in:* A. RNA therapies B. Gene augmentation/replacement C. Anti-VEGF injections D. None of the above Gene augmentation/replacement trials are underway for:* A. Retinitis pigmentosa B. Choroideremia C. People with mutations in RPGR D. All of the above Achromatopsia is a condition that causes:* A. Extreme light sensitivity B. Hearing loss C. Corneal abrasions D. Night blindness A central scotoma is the hallmark of:* A. Retinitis pigmentosa B. Stargardt disease C. Choroideremia D. Usher syndrome Patients registries for IRDs:* A. Always protect a patients’ privacy B. Help patients get on the radar of researchers and companies C. Are monitored by the FDA D. Limit the number of registrants Emerging stem cell therapies for IRDs:* A. Can be designed to protect existing retinal cells B. Can be designed to replace lost retinal cells C. Are only injected subretinally D. a. and/or b. Usher syndrome is:* A. Always inherited recessively B. A leading cause of combined hearing and vision loss C. Not easy to diagnose through genetic testing D. a. and b. 10) Which of the following are true?* A. Genetic testing provides a conclusive result in 60-70% of IRD cases B. If a patient has an IRD, it is almost certain one of their relatives has the condition C. Diabetes increases the risk of an IRD D. a. and c.