Diabetes as a Risk Factor for Dementia

A new study published in the Internal Medicine Journal, examined the association of diabetes with the onset of dementia (including Alzheimer’s disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI).

A meta-analysis of longitudinal studies that examined the relationship between diabetes and the onset of dementia or MCI were included. Nineteen studies met the inclusion criteria for this meta-analysis, that included 6184 subjects with diabetes and 38,530 subjects without diabetes. All subjects were without dementia or MCI at baseline. The quantitative meta-analysis showed that subjects with diabetes had higher risk for AD (relative risk (RR):1.46, 95% confidence interval (CI): 1.20-1.77), VD (RR: 2.48, 95% CI: 2.08-2.96), any dementia (RR: 1.51, 95% CI: 1.31-1.74) and MCI (RR: 1.21, 95% CI: 1.02-1.45) than those without. The quantitative meta-analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI.

Internal Medicine Journal, May 2012