Translating Data to Patient Care: A Case Study in HFrEF


Javed Butler, MD, MPH, MBA
Patrick H. Lehan Chair in Cardiovascular Research, Professor and Chairman, Department of Medicine
Professor of Physiology, University of Mississippi Medical Center, Jackson, MS
Javed Butler, MD, MPH, MBA

Javed Butler, MD, MPH, MBA, is the Patrick H. Lehan Chair in Cardiovascular Research, and Professor and Chairman of the Department of Medicine at the University of Mississippi Medical Center in Jackson, Mississippi. He is also a Professor of Physiology. Prior to joining the University of Mississippi, he was Charles A. Gargano Professor and Director of the Division of Cardiovascular Medicine and Co-Director of the Heart Institute at Stony Brook University, New York. He had served as the director for heart failure research at Emory University and director of the heart and heart-lung transplant programs at Vanderbilt University prior to that.

He received his medical degree from the Aga Khan University and then completed residency training at Yale University, cardiology fellowship, and advanced heart failure, and transplant fellowships at Vanderbilt University, and cardiac imaging fellowship at the Massachusetts General Hospital at the Harvard Medical School. He received his Master of Public Health Degree from Harvard University and Masters in Business Administration from Emory University.

Dr. Butler is board certified in cardiovascular medicine, advanced heart failure, and transplant medicine. His research interests focus on clinical trials in patients with heart failure. He serves on several national committees for the American College of Cardiology, American Heart Association, National Institutes of Health, U.S. Food & Drug Administration, and the Heart Failure Society of America. He is the recipient of the Simon Dack Award by the American College of Cardiology as well as the Time, Feeling, and Focus Award by the American Heart Association.

Dr. Butler has authored more than 700 peer-reviewed publications. He serves on the editorial board of several peer reviewed cardiovascular journals. He has been cited numerous times in America’s Best Doctors list.

Alanna Morris, MD, MSc, FHFSA, FACC, FAHA
Associate Professor of Medicine, Division of Cardiology, Emory University School of Medicine
Director of Heart Failure Research, Emory University Clinical Cardiovascular Research Institute, Atlanta, GA
Alanna Morris, MD, MSc, FHFSA, FACC, FAHA

Dr. Alanna A. Morris is an Associate Professor of Medicine in the Division of Cardiology at Emory University School of Medicine and the Emory Cardiovascular Clinical Research Institute. Currently she serves as the Director for Heart Failure Research and the Associate Program Director for the Clinical Investigator Track of the Cardiology Fellowship. Dr. Morris received her undergraduate degree in Biology from Xavier University of Louisiana, and her medical degree from the Harvard Medical School. She completed her residency at Brigham and Women’s Hospital in Boston, Massachusetts. Subsequently, she came to Emory University to complete fellowships in general cardiology, and advanced heart failure, and transplant. Her clinical time is spent as faculty in Emory’s Center for Heart Failure Therapy and Transplantation. She has held K23 funding from the NIH/NHLBI, and career development award funding from the Robert Wood Johnson Foundation Harold Amos Faculty Development Program. Her research program focuses on studying mechanisms that underlie race- and gender disparities in heart failure risk and progression, including the role of biologic determinants such as biomarkers of oxidative stress and endothelial dysfunction, as well as social determinants of health including neighborhood that amplify risk for adverse outcomes in heart failure.

Statement of Need

Updated practice guidelines and recently approved novel therapies provide improved strategies to optimize care for patients with heart failure (HF), particularly heart failure with reduced ejection fraction (HFrEF). Among these advances are tools and biomarkers for risk stratification, the use of sodium glucose-cotransporter-2 (SGLT2) inhibitors for appropriate patients with or without type 2 diabetes, and the role of a new soluble guanylate cyclase (sGC) inhibitor to reduce the risk of cardiovascular death and HF hospitalizations in worsening disease.

The key to improving patient care is regular clinical implementation of the new recommendations. This CMEOCast episode features two experts in HF assessing a patient who presents with worsening HFrEF, discussing additional workups that would be helpful, optimizing his current medication regimen, and sequencing newer therapies. Faculty will also discuss strategies on how to utilize shared decision-making and avoid racial and ethnic bias to ensure all patients receive appropriate, guideline-directed medical therapy.

Learning Objectives

At the end of this CME/CE activity, participants should be able to:

  • Individualize your treatment plan for patients with HFrEF to reduce readmissions, improve quality of life, and optimize long-term outcomes.
  • Recognize the prevalence of HFrEF in communities of color and address barriers to optimal care.

Financial Support

Supported by an educational grant from Merck Sharp & Dohme Corp.

Target Audience

Cardiologists, PCPs, PAs, NPs, Nurses, Pharmacists

Credit Information

Physicians (ACCME) 0.5

CME Outfitters, LLC, designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses (ANCC) 0.5

This activity is designated for 0.5 contact hours.

Pharmacists/Pharmacy Tech (ACPE) 0.5

This application-based activity is approved for 0.5 contact hours (0.05 CEUs) of continuing pharmacy credit.

PAs (AAPA) 0.5

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid until expiration date listed above. PAs should only claim credit commensurate with the extent of their participation.


Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.5 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

MIPS Improvement Activity

This activity counts towards MIPS Improvement Activity requirements under the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Dr. Butler reports that he is on the speakers bureau for AstraZeneca; Boehringer Ingelheim (BI)-Lilly Alliance; Janssen Pharmaceuticals, Inc.; and Novartis Pharmaceuticals Corporation. He is a consultant for Abbott; Adrenomed; Amgen Inc.; Applied Therapeutics; Array BioPharma Inc.; AstraZeneca; Bayer; Boehringer Ingelheim; CVRx; G3 Pharmaceuticals; Impulse Dynamics; Innolife Pharma, Inc.; Janssen Pharmaceuticals, Inc; LivaNova; Luitpold Pharmaceuticals, Inc.; Medtronic; Merck & Co., Inc.; Novartis Pharmaceuticals Corporation; Novo Nordisk; Relypsa, Inc.; Sequanna Medical; and Vifor Pharma, Inc.

Dr. Morris reports that she receives research support from the Association of Black Cardiologists; National Institutes of Health/National Heart Lung, and Blood Institute; and the Robert W. Woodruff Foundation, Inc. She also reports Institutional Research Support (paid to Emory University): Alnylam Pharmaceuticals; Amgen Inc.; Boston Scientific Corporation; Eidos Therapeutics; Ionis; Merck & Co., Inc.; MyoKardia, Inc.; National Heart, Lung, and Blood Institute (NHLBI); and Pfizer Inc. She is a shareholder with direct purchase with Gilead Sciences, Inc.

Disclosures were obtained from the CME Outfitters, LLC staff; no disclosures to report:

  • Michael Franks, APRN, AGACNP-BC, FNP-BC (peer reviewer)
  • Warren Beckman (planning committee)
  • Evan Luberger (planning committee)
  • Jan Perez (planning committee)
  • Sharon Tordoff (planning committee)

CME Outfitters, LLC and the faculty do not endorse the use of any product outside of the FDA labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patient for contraindications or dangers of use.

Obtaining Credits

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Translating Data to Patient Care: A Case Study in HFrEF
Event Date: 10/05/2021