Sleep is a complex physiological process that is mediated by a number of neurotransmitters — including histamine, acetylcholine, dopamine, gamma-amino butyric acid (GABA), norepinephrine, serotonin, glutamate, histamine, and orexin (or hypocretin). The interaction of these various neurotransmitters play different roles in the sleep-wake cycle to promote sleep and/or wakefulness in patients with narcolepsy. It is imperative that clinicians differentiate the neurotransmitters involved in the sleep-wake cycle and, when making treatment selections, apply knowledge of how novel therapies target those neurotransmitters to exert their clinical effect.
Join Drs. Thorpy and Zee in part two of a CMEOCast series on excessive daytime sleepiness (EDS) in narcolepsy as they walk clinicians through identifying the mechanisms of action (MOAs) of novel therapies and differentiating the neurotransmitters involved when individualizing therapy selection for optimal outcomes.
At the end of this CME/CE activity, participants should be able to differentiate the neurotransmitters involved in cataplexy and the sleep-wake cycle, including their differential impact on wakefulness.
Supported by an educational grant from Harmony Biosciences, LLC.
Physicians, PAs, nurse practitioners, nurses, and pharmacists specializing in psychiatry and/or primary care.
it is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and mitigate any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.
Dr. Thorpy reports the following financial relationships: Advisory Board/Consultant: Axsome Therapeutics, Inc.; Balance Therapeutics; Eisai Inc.; Flamel Technologies/Avadel; Harmony Biosciences, LLC; Jazz Pharmaceuticals, Inc.; NLS Pharmaceutics; Suven Life Sciences Limited; Takeda Pharmaceutical Company Limited; and XWPharma
Dr. Zee reports the following financial relationships: Consultant: Eisai Inc.; Harmony Biosciences, LLC; Idorsia Pharmaceuticals US Inc.; Jazz Pharmaceuticals, Inc.; Sanofi-Aventis; and Takeda Pharmaceutical Company Limited. Grants: Vanda Pharmaceuticals (Paid to Northwestern University)
Disclosures were obtained from the CME Outfitters, LLC staff: No disclosures to report.
Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.
NOTE: Pharmacist CE Universal Activity Number, Enduring: JA0007185-0000-22-031-H01-P.
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