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Beyond Dopamine: Glutamate as a Target in Schizophrenia

An interesting review in ISRN Pharmacology, a peer-reviewed, open access journal, describes that for the last 60 years, antipsychotic pharmacology targeting antagonism of dopamine (DA) D2 receptors have been the primary treatment choice for schizophrenia. The clinical improvement seen …

The Influence of Genetics on High ACPA Levels in Rheumatoid Arthritis

A recent study in the Journal Arthritis and Rheumatism assessed whether extreme production of a very specific biomarker in rheumatoid arthritis (RA) called anti-citrullinated protein antibodies (ACPAs) has any genetic associations.

High levels of ACPA are frequently associated with a …